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When is the best time to take Zetia?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Dec 18, 2023.

Can I take Zetia at the same time as my other cholesterol medications?

Official answer

by drugclasses.com

There is no best time to take Zetia, as it works exactly the same whether you take it in the morning, afternoon or evening.
Zetia is taken once a day, at the same time each day and it can be taken with or without food. It is important to choose a time to take it that is most convenient for you and when you are most likely to remember to take it.

Can I take Zetia at the same time as my other cholesterol medications?

Zetia is a cholesterol lowering medication and is sometimes prescribed to be taken with other cholesterol medications.
Zetia can be taken at the same time as these cholesterol lowering medications:

  • fenofibrate
  • atorvastatin
  • lovastatin
  • simvastatin
  • pravastatin
  • fluvastatin.

You should not take Zetia together with a statin medicine if you have active liver disease or if you are pregnant or breastfeeding a baby.

Zetia needs to be taken at a different time from these cholesterol lowering medications:

  • cholestyramine
  • colestipol
  • colesevelam.

If you have taken cholestyramine, colestipol, or colesevelam you need to wait at least 4 hours before taking Zetia.

If you have taken Zetia you need to wait 2 hours before taking cholestyramine, colestipol, or colesevelam.

Bottom line:
Zetia can be taken:

  • at anytime of the day
  • as long as it is the same time each day
  • with or without food.
References

Read next

Does Zetia (ezetimibe) cause memory loss?

Memory loss is not a side effect of Zetia (ezetimibe) when it is used alone to treat high cholesterol. Zetia is often used with diet and other cholesterol lowering medications like statins which have been linked with cognitive impairment (memory loss, forgetfulness, or confusion). Continue reading

Can Zetia (ezetimibe) cause liver damage?

Yes, Zetia (ezetimibe) can cause liver damage, although it is very rare. Monitor liver enzymes for the development of serious toxic hepatitis and consider ezetimibe discontinuation if it develops. Perform liver tests during ezetimibe initiation and regularly thereafter and consider withdrawal of ezetimibe and/or the statin (if coadministered) should an increase in ALT or AST ≥3 X upper limit of normal (ULN) persist. Continue reading

How does Zetia (ezetimibe) work to lower cholesterol?

It reduces cholesterol absorption from the small intestine so there is less cholesterol delivered to the liver. This means there is a lower amount of cholesterol stored in the liver, which leads to more cholesterol being cleared from the blood. Continue reading

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