Does Fetzima help with anxiety?
Although Fetzima is not FDA approved to treat anxiety, it is sometimes used off-label for this condition. Research has suggested that Fetzima does appear to help with anxiety because an improvement was seen in anxiety symptoms monitored in tools such as the Montgomery-Asberg Depression Rating Scale (MADRS) for inner tension and the Hamilton Depression Rating Scale (HAMD17) that were used in several clinical trials for depression. Unfortunately, most trials of Fetzima excluded people from participating if they had a comorbid anxiety disorder unless it was social anxiety disorder, generalized anxiety disorder, or a specific phobia, but even then the effect of Fetzima on allowable anxiety disorders was never analyzed.
More good-quality trials are needed to fully determine the benefits of Fetzima for anxiety, but the available research suggests it does improve anxiety symptoms in most people, which is promising because approximately 60% of people with major depression also have an anxiety disorder.
However, in a small subset of people, Fetzima may actually increase anxiety, although this usually resolves within a couple of weeks of continuing to take Fetzima. Talk to your doctor if you develop anxiety or your symptoms of anxiety worsen while taking Fetzima. Symptoms of anxiety include feeling nervous, restless, or tense; having a sense of impending danger, panic, or doom; sweating, trembling, or an increased heart rate.
Fetzima is an oral, extended-release capsule that may be used to treat moderate-to-severe depression in adults. It is a dual neurotransmitter reuptake inhibitor that has greater selectivity for inhibiting norepinephrine reuptake than serotonin reuptake.
References
- Fetzima (levomilnacipran hydrochloride) Updated 10/2019. Allergan, Inc. https://www.drugclasses.com/pro/fetzima.html
- Asnis GM, Henderson MA. Levomilnacipran for the treatment of major depressive disorder: a review. Neuropsychiatr Dis Treat. 2015 Jan 9;11:125-35. doi: 10.2147/NDT.S54710. PMID: 25657584; PMCID: PMC4295915.
Read next
How long does it take Fetzima to leave your system?
Fetzima takes approximately 60 hours or 2.5 days to leave your system following the last dose. Experts calculate this period using the half-life of a drug. The half-life of Fetzima is about 12 hours and experts agree that it takes up to 5 half-lives for a drug without active metabolites to be completely removed from the body. This calculates out to 60 hours for Fetzima. Continue reading
Does Fetzima cause weight loss or weight gain?
Research has shown that Fetzima has no overall effect on weight and does not cause weight gain or loss in studies that followed people for up to one year. Data pooled from short-term trials show an average overall weight loss of 0.59kg with Fetzima and a weight gain of 0.02kg with placebo. The number of patients who reported a more than 7% increase in their weight was 0.6% with Fetzima and 0.9% with placebo. The number of patients reporting a weight loss of more than 7% was 1.6% with Fetzima and 1% with placebo. In a 1-year, unblinded safety study, an average weight loss of 0.55kg was reported with Fetzima. Generally, there was a trend towards weight loss with Fetzima but this was not considered significant. Continue reading
Does Fetzima cause hair loss?
Hair loss is not a common side effect of Fetzima and is not listed in the product information but post-marketing reports indicate hair loss has been reported in approximately 1.2% of people who reported side effects while taking Fetzima. Hair loss was more likely to occur in women, with 54% of cases documented in those aged 50 to 59. Continue reading
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Drug information
- Fetzima Information for Consumers
- Fetzima prescribing info & package insert (for Health Professionals)
- Side Effects of Fetzima (detailed)
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