Does Xarelto increase or decrease blood pressure?
Does Xarelto cause hypertension or hypotension?
High blood pressure (hypertension) and low blood pressure (hypotension) are not listed as side effects of Xarelto (rivaroxaban), a direct oral anticoagulant (DOAC) and factor Xa inhibitor used to treat and prevent blood clots.
However, Xarelto is a blood thinner and its use is associated with an increased risk of bleeding, which can be serious and may lead to death. If Xarelto causes excessive bleeding it can cause a sudden drop or decrease in your blood pressure and shock. Signs of shock include dizziness, weakness, confusion, anxiety, rapid breathing, pale skin and reduced urine output.
Shock caused by excessive bleeding occurs when there isn’t enough blood flow in your body, which results in your organs not getting enough nutrients and oxygen to work properly.
Xarelto may also cause severe allergic reactions (hypersensitivity), which can also result in a sudden drop in blood pressure. Other symptoms of a severe allergic reaction include hives and breathing difficulties, difficulty swallowing, and swelling of the face, lips, mouth, tongue or throat.
References
- Food and Drug Administration (FDA). Xarelto Product Label. [Accessed November 8, 2022]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/022406Orig1s039,202439Orig1s038correctedlbl.pdf.
- MedlinePlus. Hypovolemic shock. November 13, 2021. [Accessed November 8, 2022]. Available from: https://medlineplus.gov/ency/article/000167.htm.
Read next
Xarelto vs Eliquis: How do they compare?
Xarelto (rivaroxaban) and Eliquis (apixaban) are novel anticoagulants that make blood less likely to clot (also called thinning the blood). Both belong to the class of medicines known as factor Xa (FXa) inhibitors and they are two of the most popular blood thinners on the market. Either one may be used to reduce the risk of stroke or treat and prevent blood clots in conditions such as DVT. Continue reading
Switching from Eliquis to Xarelto: What do I need to know?
Follow your healthcare provider's instructions when switching from Eliquis to Xarelto. When switching from Eliquis to Xarelto you should stop taking Eliquis and then start taking Xarelto at the time your next dose of Eliquis is due. Do not take Eliquis and Xarelto at the same time. Continue reading
How long before surgery should Xarelto be stopped?
Ideally, Xarelto (rivaroxaban) should be stopped at least 24 hours before surgery in a person with normal renal function who is undergoing a low bleeding risk procedure or 48 to 72 hours before if the procedure is high-risk. For somebody with impaired renal function (CLCR of 30-50 ml/min) undergoing a low bleeding risk procedure, Xarelto should be stopped 48 hours before, or 48 to 72 hours before if the procedure is high risk. Continue reading
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Drug information
- Xarelto Information for Consumers
- Xarelto prescribing info & package insert (for Health Professionals)
- Side Effects of Xarelto (detailed)
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- Xarelto (109 questions, 417 members)
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