Augmentin ES-600 Dosage
Generic name: AMOXICILLIN
600mg in 5mL, CLAVULANATE POTASSIUM
42.9mg in 5mL
Dosage form: powder, for oral suspension
Drug class: Beta-lactamase inhibitors
Medically reviewed by drugclasses.com. Last updated on Oct 28, 2022.
Important Administration Instructions
To minimize the potential for gastrointestinal intolerance, AUGMENTIN ES-600 should be taken at the start of a meal. Absorption of clavulanate potassium may be enhanced when AUGMENTIN ES-600 is administered at the start of a meal.
Dosage in Pediatric Patients
Pediatric patients 3 months and older: Based on the amoxicillin component (600 mg/5 mL), the recommended dose of AUGMENTIN ES-600 is 90 mg/kg/day divided every 12 hours, administered for 10 days (see chart below). This dose provides 6.4 mg/kg/day of the clavulanic acid component.
Body Weight (kg) |
Volume of AUGMENTIN ES-600 for oral suspension providing 90 mg/kg/day |
8 | 3 mL twice daily |
12 | 4.5 mL twice daily |
16 | 6 mL twice daily |
20 | 7.5 mL twice daily |
24 | 9 mL twice daily |
28 | 10.5 mL twice daily |
32 | 12 mL twice daily |
36 | 13.5 mL twice daily |
Pediatric patients weighing 40 kg and more: Experience with AUGMENTIN ES-600 in this group is not available.
Dosage in Adult Patients
Experience with AUGMENTIN ES-600 in adults is not available and adults who have difficulty swallowing should not be given AUGMENTIN ES-600 in place of the 500 mg or 875 mg tablet of AUGMENTIN.
Dosage in Patients with Hepatic Impairment
Hepatically impaired patients should be dosed with caution and hepatic function monitored at regular intervals [see Warnings and Precautions (5)].
Preparation of the Oral Suspension
Directions for Mixing Oral Suspension: Prepare a suspension at time of dispensing as follows: Tap bottle until all powder flows freely. Measure the total amount of water (see chart below) to be added in two parts. Add approximately 2/3 of the total amount of water for reconstitution, replace cap and shake vigorously to suspend powder. Add remainder of the water (that had been measured), replace cap and again shake vigorously.
AUGMENTIN ES-600, USP | |
Bottle Size | Amount of Water Required for Reconstitution |
75 mL | 70 mL |
125 mL | 110 mL |
200 mL | 180 mL |
Each teaspoonful (5 mL) will contain 600 mg of amoxicillin as the trihydrate, and 42.9 mg of clavulanic acid as the potassium salt.
Shake oral suspension well before each use. Suspension must be refrigerated. Discard after 10 days. Suspension is off-white at time of reconstitution; some color change is normal during the dosing period.
Flavoring Information: For patients who wish to alter the taste of AUGMENTIN ES-600, immediately after reconstitution 1 drop of FLAVORx™ (apple, banana cream, bubble gum, cherry, or watermelon flavor) may be added for every 5 mL of AUGMENTIN ES-600. The resulting suspension is stable for 10 days under refrigeration. Stability of AUGMENTIN ES-600 when mixed with other flavors distributed by FLAVORx has not been evaluated for flavors other than the 5 flavors listed above.
Switching between Dosage Forms and between Strengths
AUGMENTIN ES-600 does not contain the same amount of clavulanic acid (as the potassium salt) as any of the other suspensions of AUGMENTIN. AUGMENTIN ES-600 contains 42.9 mg of clavulanic acid per 5 mL, whereas the 200 mg/28.5 mg per 5 mL suspension of AUGMENTIN contains 28.5 mg clavulanic acid per 5 mL and the 400 mg/57 mg per 5 mL suspension of AUGMENTIN contains 57 mg clavulanic acid per 5 mL. Therefore, the 200 mg/28.5 mg per 5 mL and 400 mg/57 mg per 5 mL suspensions of AUGMENTIN should not be substituted for AUGMENTIN ES-600 as they are not interchangeable.
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