Erleada Dosage

Generic name: APALUTAMIDE 60mg
Dosage form: tablet, film coated
Drug classes: Antiandrogens, Hormones / antineoplastics

Medically reviewed by drugclasses.com. Last updated on Jul 16, 2024.

Recommended Dosage

The recommended dose of ERLEADA is 240 mg administered orally once daily. This could be administered as one 240 mg tablet or four 60 mg tablets. Swallow the tablet(s) whole. Do not crush or split tablet(s). ERLEADA can be taken with or without food.

Patients should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had a bilateral orchiectomy.

Dosage Modification

If Grade 3 or greater adverse reactions, or other intolerable adverse reactions occur, withhold ERLEADA. Consider permanent discontinuation of ERLEADA for Grade 3 or 4 cerebrovascular and ischemic cardiovascular events [see Warnings and Precautions (5.1)] . Permanently discontinue ERLEADA for confirmed SCARs or for other Grade 4 skin reactions [see Warnings and Precautions (5.5)and Adverse Reactions (6.1)] . For other adverse reactions, when symptoms improve to less than or equal to Grade 1 or original grade, resume ERLEADA at the same dose or a reduced dose (180 mg or 120 mg), if warranted.

Alternate Methods of Administration

Disperse Tablet(s) in Water and Administer with Orange Juice, Applesauce, or Additional Water

For patients who cannot swallow tablets whole, the recommended dose of ERLEADA tablet(s) can be dispersed in non-carbonated water and then administered with either orange juice, applesauce, or additional water as follows:

Place the entire prescribed dose of ERLEADA tablet(s) in a cup. Do not crush or split the tablet(s).
For one 240 mg tablet:Add about 2 teaspoons (10 mL) of non-carbonated water to make sure that the tablet is completely immersed in water.
For 60 mg tablets (prescribed dose of 240 mg, 180 mg, or 120 mg):Add about 4 teaspoons (20 mL) of non-carbonated water to make sure that the tablets are completely immersed in water.
Wait 2 minutes until the tablet(s) are broken up and spread out, then stir the mixture.
Add 2 tablespoons (30 mL) of either orange juice, applesauce, or additional water and stir the mixture.
Swallow the mixture immediately.
Rinse the cup with enough water to make sure the whole dose is taken and drink it immediately.

Do not store ERLEADA that is mixed with non-carbonated water, orange juice, or applesauce for later use.

Administer Tablet(s) Through a Feeding Tube

ERLEADA tablet(s) can be administered through a feeding tube 8 French or greater as follows:

For one 240 mg tablet:Place the tablet in the barrel of the syringe (use at least a 20 mL syringe) and draw up 10 mL of non-carbonated water into the syringe.
For 60 mg tablets (prescribed dose of 240 mg, 180 mg, or 120 mg):Place the entire prescribed dose of ERLEADA tablets in the barrel of the syringe (use at least a 50 mL syringe) and draw up 20 mL of non-carbonated water into the syringe.
Wait 10 minutes and then shake vigorously to disperse contents completely.
Administer immediately through the feeding tube.
Refill the syringe with non-carbonated water and administer. Repeat until no tablet residue is left in the syringe or feeding tube.