Does Caplyta cause weight gain?
Caplyta (lumateperone) treatment is not associated with the weight gain that some other antipsychotic drugs are. Caplyta is an atypical antipsychotic that is used to treat schizophrenia and bipolar depression in adults.
Results from a number of trials combined together showed that the weight gain observed in patients treated with Caplyta was similar to the weight gain observed in patients who received placebo.
Positive results were also reported by a study that followed patients for one year after they switched from standard of care to Caplyta. Significant improvements in mean body weight were observed during the year of treatment (-2.1 kg, P <0.001) when mean body weights from the beginning and end of the year were compared. Significant reductions in body mass index (BMI) and waist circumference were also observed.
References
- Food and Drug Administration (FDA). Caplyta. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/209500s009lbl.pdf. [Accessed May 4, 2022].
- Satlin A, Durgam S, Vanover KE, et al. M205. LONG-TERM SAFETY OF LUMATEPERONE (ITI-007): METABOLIC EFFECTS IN A 1-YEAR STUDY. Schizophr Bull. 2020;46(Suppl 1):S214. doi:10.1093/schbul/sbaa030.517.
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What is the mechanism of action for Caplyta?
Caplyta (lumateperone) is thought to work by changing the activity of certain chemicals called neurotransmitters in the brain. These neurotransmitters include dopamine, glutamate, and serotonin. Continue reading
How long does it take Caplyta to work?
Patient with schizophrenia started to show improved Positive and Negative Syndrome Scale (PANSS) total scores after one week of treatment with Caplyta (lumateperone), according to the results of a phase III trial. PANSS is a scale used to measure the severity of schizophrenia symptoms. Symptoms continue to improve the longer you take the drug. Continue reading
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Drug information
- Caplyta Information for Consumers
- Caplyta prescribing info & package insert (for Health Professionals)
- Side Effects of Caplyta (detailed)
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