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Does Emgality raise blood pressure?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on June 12, 2024.

Official answer

by drugclasses.com

Emgality (galcanezumab-gnlm) is unlikely to raise blood pressure. During clinical trials (EVOLVE-1, EVOLVE-2, REGAIN, and CONQUER), less than 1% of people taking Emgality reported high blood pressure as a side effect.

A study of about 19,000 patients who took anti-CGRP treatment (including Emgality) found that anti-CGRP treatment is safe regarding blood pressure in patients without high blood pressure. However, researchers found that patients who already had high blood pressure and took an anti-CGRP treatment were more likely to need additional medications to control their blood pressure during treatment.

Only minimal changes in blood pressure were observed during a phase 3, 12-month safety study of Emgality in patients with migraine.

Whether you are taking Emgality or not, it is important to get your blood pressure checked regularly when you visit your healthcare provider. High blood pressure can damage many parts of your body, and lead to serious problems such as kidney failure, stroke, and heart attack.

Emgality is an injectable medication used to prevent migraines and treat episodic cluster headache. The most common side effect reported with using Emgality is injection site reactions. These can include pain, redness, and itching at the area where you inject the medication.

References

Camporeale, A., et. al. (2018). A phase 3, long-term, open-label safety study of Galcanezumab in patients with migraine. In: BMC Neurology. Accessed 06/10/2024 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234796/

Canadian Agency for Drugs and Technologies in Health. (2022). Galcanezumab (Emgality): CADTH Reimbursement Review: Therapeutic area: Prevention of migraine [Internet]. Accessed 06/10/2024 at https://www.ncbi.nlm.nih.gov/books/NBK596661/

Emgality [package insert]. (2021). Eli Lilly and Company. Accessed 06/12/2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=33a147be-233a-40e8-a55e-e40936e28db0

Wang, K., et. al. (2023). Trajectory of blood pressure after initiating anti-calcitonin gene-related peptide treatment of migraine: a target trial emulation from the veterans health administration. In: The Journal of Headache and Pain. Accessed 06/12/2024 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426172/

Read next

Does Emgality cause weight gain?

Weight gain is not listed as a side effect in the product information for Emgality (galcanezumab) and phase 3 studies reported that there was no difference in the amount of weight gained between people taking Emgality and those assigned placebo (an inactive treatment). Anecdotally, however, some people have reported gaining weight. Continue reading

How long does it take for Emgality to work?

When Emgality (galcanezumab) is administered to prevent migraine, it starts working within one month of initiation, but it may take up to five or six months for the full effects of Emgality to be seen. When Emgality is administered for the treatment of cluster headache, it starts working within one week of starting treatment, but it may take up to three weeks for the full effects to be seen. Continue reading

Do Emgality injections hurt?

Yes, Emgality injections may hurt. Pain at the injection site is one of the most common side effects reported with Emgality, with 18% of people experiencing it. Some people also experience excessive amounts of pain with Emgality with comments on blog sites stating "It was one of the most painful things I've ever felt" and "Thigh, thigh, then arm, all were unreal painful....coming from the girl who falls asleep and takes naps during 6hr tattoo sessions". Continue reading

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