Is Entyvio used to treat Crohn’s disease?

Entyvio (vedolizumab) may be used to treat moderately to severely active Crohn's disease (CD) in adults. It helps to control inflammation in the gut when other medications for CD have not worked well enough or have side effects that are difficult for the person with CD to tolerate.

In patients with Crohn’s disease, 15% of those receiving Entyvio in 2 studies were in remission at 6 weeks, compared to 7% and 12% on placebo. Only one study was found to be statistically significant.

In a follow-up study of people who had previously responded to Entyvio in a previous trial, 39% were in clinical remission at week 52 and 44% had a clinical response by week 52. Of those who had previously been prescribed corticosteroids, 32% were now corticosteroid-free.

Individual results may vary. Not every patient will respond to Entyvio. Entyvio is usually administered through an intravenous (IV) infusion by a healthcare provider for the first 2 doses, and as a subcutaneous (SC) (under the skin) injection for subsequent doses that you can self-administer at home using a prefilled pen or syringe.