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How long does it take for Aricept to work?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on July 13, 2024.

Official answer

by drugclasses.com

Aricept (donepezil) may start working within 3 weeks of starting treatment to improve Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) scores, but can take up to 4-6 weeks to be effective for some people. The ADAS-cog test measures performance on language and memory to help determine the extent of cognitive impairment.

How do I know if donepezil is working?

As Aricept begins to work, you may remember things easier and be able to concentrate better. It might also become easier to manage daily activities such as bathing, dressing, and eating. Aricept is not a cure for Alzheimer’s disease, and only provides modest benefits.

Not everyone responds to Aricept the same way. Some patients might experience significant improvements in their symptoms, while others might only see mild benefits or no improvement at all. If you haven’t noticed an improvement in your symptoms after taking Aricept for 4-6 weeks, let your doctor know. They might be able to raise your dose to see if that helps, or recommend a different treatment option.

References

Aricept [package insert]. (Updated Dec 2021). Eisai Inc. Accessed 07/12/2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=98e451e1-e4d7-4439-a675-c5457ba20975

Birks, J. S., et. al. (2018). Donepezil for dementia due to Alzheimer's disease. DOI: https://doi.org/10.1002%2F14651858.CD001190.pub3

National Health Services. (Updated March 2023). Common questions about donepezil. Accessed 07/12/2024 at https://www.nhs.uk/medicines/donepezil/common-questions-about-donepezil/

Rockwood, K., et. al. (2007). The clinical meaningfulness of ADAS-Cog changes in Alzheimer's disease patients treated with donepezil in an open-label trial. In: BMC Neurology. DOI: https://doi.org/10.1186%2F1471-2377-7-26

Read next

Can Aricept be stopped abruptly?

Do not stop taking Aricept (donepezil) without consulting your healthcare provider. If you stop taking Aricept abruptly, your Alzheimer’s disease symptoms can worsen. It is generally recommended to slowly taper down your dose of Aricept before stopping completely. Your doctor can help you stop Aricept safely. Continue reading

When is the best time to take Aricept (donepezil)?

The manufacturer recommends taking Aricept (donepezil) in the evening just before bedtime. Aricept can cause nausea and vomiting in some patients, as well as dizziness. Taking it before bedtime may help these side effects be less noticeable. However, your prescriber might recommend taking Aricept at a different time if it’s interfering with your sleep. Continue reading

What are 7 key Aricept side effects to watch out for?

Common side effects of Aricept include nausea, diarrhea, trouble sleeping, muscle cramps, and low appetite. For most people, these side effects last a few weeks and get better with continued use of Aricept. Continue reading

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