How long does ibuprofen take to work?
Ibuprofen takes about 20 to 30 minutes to start working and its maximum effects are usually seen within 1 to 2 hours. For some people who have had pain for weeks or months, it may take several days of regular dosing before you notice some relief.
Food can increase the time it takes for ibuprofen to be absorbed, although it won’t affect how much is absorbed. Taking ibuprofen on an empty stomach may give you faster symptom relief, although it may increase the risk of stomach-related side effects, such as indigestion.
One dose of ibuprofen provides pain relief for four to six hours. But it may take at least 10 hours for your body to completely rid your system of ibuprofen. This is because it has a half life of 1.9 to 2.2 hours and experts generally agree it takes 4 to 5 half lives for your body to completely eliminate ibuprofen, which equals approximately 10 hours.
References
- Ibuprofen. Revised 05/2022. Slate Run Pharmaceuticals, LLC https://www.drugclasses.com/pro/ibuprofen.html
Read next
Naproxen vs ibuprofen: What's the difference?
Ibuprofen is short acting, while naproxen is long acting and more likely to cause an upset stomach. Naproxen and ibuprofen are both NSAIDs so they are similar in many ways, but there are important differences. Continue reading
What's the difference between aspirin and ibuprofen?
Even though aspirin and Ibuprofen are both NSAIDs (nonsteroidal anti-inflammatory drugs) and work similarly, there are several differences between the two drugs and they are not considered interchangeable. Continue reading
Can you take ibuprofen on an empty stomach?
Despite popular belief that you have to take ibuprofen with food, you can take ibuprofen on an empty stomach and this will give you faster pain relief than taking it with food. Food increases the time it takes for ibuprofen to be absorbed, although it won't affect how much is absorbed. There is actually no evidence that taking ibuprofen with food prevents gastric irritation – ibuprofen at OTC doses has a low incidence of gastric irritation anyway. Continue reading
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Drug information
- Ibuprofen Information for Consumers
- Ibuprofen prescribing info & package insert (for Health Professionals)
- Side Effects of Ibuprofen (detailed)
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