How long does Tepezza stay in your system?
Tepezza stays in your system approximately 100 days after the last dose. This is calculated by looking at the average half-life of Tepezza which is 20 days. The half-life is the time it takes for 50% of a medicine to be eliminated from the body. Research has shown that it takes 4 to 5 half-lives for a medicine to be fully cleared from the body which calculates out to 80 to 100 days or 11 to 14 weeks for Tepezza.
Women of childbearing capability should use an effective form of birth control (contraception) before starting Tepezza, during treatment, and for at least 6 months after their last Tepezza dose. Experts also recommend males taking Tepezza should ensure their female partners are using effective birth control while they are taking it and for 6 months after the last dose.
References
- Tepezza Tepezza.com https://www.tepezza.com/about-tepezza/frequently-asked-questions#:~:text=Be%20sure%20to%20tell%20your,after%20your%20last%20TEPEZZA%20treatment.
- Tepezza (teprotumumab). Updated 02/2022. Horizon Therapeutics USA, Inc. https://www.drugclasses.com/pro/tepezza.html
- Douglas, Raymond S. MD, PhD; Wang, Yao MD; Dailey, Roger A. MD; Harris, Gerald J. MD; Wester, Sara T. MD; Schiffman, Jade S. MD; Tang, Rosa A. MD; Fowler, Brian MD; Fleming, James MD; Smith, Terry J. MD Teprotumumab in Clinical Practice: Recommendations and Considerations From the OPTIC Trial Investigators, Journal of Neuro-Ophthalmology: December 2021 - Volume 41 - Issue 4 - p 461-468 doi: 10.1097/WNO.0000000000001134
Read next
What are monoclonal antibodies?
Monoclonal antibodies (mAbs) are man-made proteins that mimic the natural antibodies produced by our immune systems. Monoclonal antibodies can be formulated into medicines to treat various types of illnesses, such as cancer, rheumatoid arthritis or psoriasis. Continue reading
How does Tepezza work, what's the mechanism of action?
Tepezza (teprotumumab) is an inhibitor of insulin-like growth factor-1 receptor (IGF-1R) used to treat Thyroid Eye Disease (TED). It is a monoclonal antibody that blocks IGF-1R activation and signaling. Tepezza decreases eye bulging (proptosis) by decreasing inflammation, preventing muscle and fat tissue remodeling, and preventing tissue expansion behind the eye. Continue reading
Tepezza before and after, what should I expect?
After treatment, Tepezza has been shown in 24-week long clinical studies to reduce the eye bulging, double vision, eye pain, redness and swelling that may occur before treatment with TED. Some patients may have improvement in symptoms as early as 6 weeks. In addition, an improvement in vision (such as reading or watching TV) and in the patient’s appearance was also seen. Continue reading
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Drug information
- Tepezza Information for Consumers
- Tepezza prescribing info & package insert (for Health Professionals)
- Side Effects of Tepezza (detailed)
Related support groups
- Tepezza (11 questions, 8 members)