How is the new Primatene Mist different to the old formulation?
Medically reviewed by drugclasses.com. Last updated on Nov 21, 2023.
Why was the old Primatene Mist removed from the market?
The new Primatene Mist is a metered dose inhaler (MDI) of epinephrine containing hydrofluoroalkane (HFA) propellants instead of CFC propellants.
In 2011, OTC Primatene Mist (epinephrine) was removed from U.S. pharmacy shelves due to international agreements to phase out products worldwide containing ozone-depleting chlorofluorocarbons (CFCs). However, in 2018 Primatene Mist returned to the U.S. market with a newly patented formulation.
- Primatene Mist is used for the temporary relief of mild symptoms of intermittent asthma (eg, wheezing, chest tightness, shortness of breath) in patients aged ≥12 years.
- The new mixture of Primatene Mist is a metered dose inhaler (MDI) of epinephrine containing hydrofluoroalkane (HFA) propellants instead of CFC propellants.
- The product’s new inhalation delivery system also provides a built-in spray indicator and a metal canister which replaces the original glass container.
- Primatene Mist returns as the only FDA-approved asthma inhaler available without a prescription in the U.S.
- View the step-by-step directions for use below.
If you have used Primatene Mist for asthma symptoms, see a doctor if:
- you are not better in 20 minutes or get worse
- need more than 8 inhalations in 24 hours
- have more than 2 asthma attacks in a week.
These may be signs that your asthma is getting worse. Asthma can be a life threatening condition if not properly treated.
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Can you bring an EpiPen on a plane?
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Drug information
- Primatene Mist Information for Consumers
- Primatene Mist prescribing info & package insert (for Health Professionals)
- Side Effects of Primatene Mist (detailed)
Related support groups
- Primatene Mist (3 questions, 15 members)
- Asthma (115 questions, 471 members)