Can I take omeprazole in the morning and famotidine at night?
Yes, you could take omeprazole in the morning and famotidine at night but there are not many studies investigating this approach. Preliminary results suggest that taking your medication this way may provide superior control of gastric acid secretion at night without compromising the effectiveness of omeprazole in the morning. More research is needed.
One small study that looked at the combination of famotidine and omeprazole as a single pill reported a shortening of the time to reach a more favorable gut ph of >4 and a longer duration of effect. Another study that used Pepcid Complete (a combination formulation that contains famotidine and 2 antacids, calcium carbonate and magnesium hydroxide) reported that omeprazole in the morning and Pepcid Complete at night were superior than omeprazole morning and night.
References
- Fändriks L, Lönroth H, Pettersson A, Vakil N. Can famotidine and omeprazole be combined on a once-daily basis? Scand J Gastroenterol. 2007 Jun;42(6):689-94. doi: 10.1080/00365520601026665. PMID: 17505990.
- New Study Finds Nocturnal Acid Breakthrough Better Controlled With OTC Combination Heartburn Product Than Second Dose of Prescription PPI https://johnsonandjohnson.gcs-web.com/static-files/011fbc97-b98b-4a0d-aed9-af689a4fbf64
Read next
Is famotidine safer than omeprazole for heartburn?
Famotidine is usually the first choice to treat occasional heartburn if your symptoms occur less than two times per week. It can be used as needed, provides quick relief (within 15 to 30 minutes), and is usually less expensive than omeprazole. Omeprazole may be an option if your heartburn occurs two or more days per week. Both products are available without a prescription. Continue reading
Can you take famotidine long term?
Famotidine (brand name: Pepcid AC, Zantac 360) should not be used for longer than 14 days if you are treating heartburn symptoms. Famotidine may be used for a longer period under the direction of your healthcare provider for treatment of intestinal or stomach ulcers, gastroesophageal reflux (GERD), erosive esophagitis, or other acid-related conditions. Continue reading
Pantoprazole vs. omeprazole: What's the difference between them?
Pantoprazole and omeprazole are both medicines from the class of medications called proton pump inhibitors (PPIs). The approved uses for pantoprazole and omeprazole differ slightly, but they are all disorders related to too much stomach acid. Continue reading
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Drug information
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