Does Tyrvaya reduce inflammation?
Tyrvaya does not reduce inflammation, it targets the trigeminal parasympathetic pathway which stimulates the lacrimal functional unit – an integrated system consisting of the lacrimal glands, surface of the eye, goblet glands and meibomian glands, and the nerves that connect them – to improve the quality and quantity of tear film produced. The trigeminal parasympathetic pathway is accessible through the nose, which is why Tyrvaya is produced as a nasal spray. This allows effective treatment of dry eye without the burning and stinging often associated with eye drops.
Dry eye is caused by an unstable tear film, which makes the cornea (the transparent layer at the front of the eye) vulnerable to damage and inflammation. Most dry eye products try to replicate natural tears. But tears are very complex and composed over 1500 proteins, lipids, and mucins with strong antibacterial and anti-inflammatory properties. By stimulating the trigeminal parasympathetic pathway, Tyrvaya improves the quality and quantity of our own tears, rather than trying to replace tears.
References
- FDA approves Oyster Point Pharma’s Tyrvaya as the first nasal spray for dry eye disease. January 1, 2022. Ophthalmology Management. https://www.ophthalmologymanagement.com/issues/2022/january-2022/rx-perspective
- Neural Tributaries. Dry Eyeland. https://www.dryeyeland.com/neural-tributaries#:~:text=Tear%20film%20homeostasis%20is%20predominantly%20regulated%20by%20the%20trigeminal%20parasympathetic%20pathway.&text=The%20trigeminal%20nerve%20is%20the,and%20maintains%20tear%20film%20homeostasis.
- McKown, R. L., Wang, N., Raab, R. W., Karnati, R., Zhang, Y., Williams, P. B., & Laurie, G. W. (2009). Lacritin and other new proteins of the lacrimal functional unit. Experimental eye research, 88(5), 848–858. https://doi.org/10.1016/j.exer.2008.09.002
Read next
What is the mechanism of action of Tyrvaya?
Tyrvaya works by activating a pathway in the nose that is responsible for your own natural tear production. It is thought to work as an agonist by binding to the nicotinic acetylcholine (nACh) receptor. This binding activates the trigeminal parasympathetic pathway in the nose to increase basal tear production. Continue reading
How long does a bottle of Tyrvaya last?
A bottle of Tyrvaya will last 15 days. This is because it contains 60 sprays and the recommended dose is ONE spray into BOTH nostrils Twice daily. This means you will use 4 sprays per day in total which will last 15 days. Each prescription of Tyrvaya comes with 2 glass nasal spray bottles which will last you 30 days in total. Continue reading
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