What happens when you stop Evenity?

Within months of stopping Evenity (romosozumab), its effects on bone formation and resorption will diminish. Studies suggest that if you stop taking Evenity after three months, it can stay in the body for about 2 months. However, it can take up to 12 months for P1NP and CTX levels to return to what they were before you started treatment.

Do not stop taking Evenity without speaking with your healthcare provider. Doing so can put you at risk for fractures.

What is Evenity used for?

Evenity is an injectable medication that may be used to treat osteoporosis in postmenopausal women at high risk for fracture. This includes women with a history of fracture due to osteoporosis or who have multiple risk factors for fracture. It is only approved for use up to 12 months.

How does Evenity work?

Evenity is a sclerostin inhibitor. Sclerostin is a protein that stops bone formation. By blocking sclerostin, Evenity promotes bone formation and decreases bone resorption. Studies show that Evenity increases the bone formation marker called procollagen type 1 N-telopeptide (P1NP). It also decreases the bone resorption marker type 1 collagen C-telopeptide (CTX).

What is the half-life of Evenity?

After receiving three doses of Evenity (one dose of 3 mg/kg per month for three months in a row), the half-life is 12.8 days. This means that at 12.8 days, 50% of the maximum concentration of Evenity in the body is eliminated.

Talk to your healthcare provider if you need to stop taking Evenity. They can recommend other treatment options to keep your bones healthy and prevent fractures.