Can Imitrex (sumatriptan) cause rebound headaches?
Yes, Imitrex (sumatriptan) can cause rebound headaches (also known as medication-overuse headaches). Rebound headaches are more likely to occur if you take Imitrex alone or a combination of Imitrex and other headache medications (e.g., opioids, analgesics) for 10 or more days per month.
Contact your healthcare provider if your headaches seem to be getting worse while taking Imitrex. They can help you determine if you are experiencing medication-overuse headaches and offer guidance on how to treat this disorder.
What is a rebound headache?
A rebound headache is a headache that occurs on 15 or more days per month in patients with a pre-existing headache condition who have used headache medication for 10 or more days per month for over three months. All types of headache medications, including over-the-counter medications, can lead to rebound headaches.
Symptoms of a rebound headache could look like migraine-like daily headaches, or an increase in migraine attacks. Rebound headaches typically occur in the morning and are difficult to treat.
Certain people are at a higher risk for rebound headaches than others. For example, patients who tend to get headaches often are at a higher risk for rebound headaches. Other risk factors for rebound headaches include:
- Younger than 50 years old
- Family history of rebound headaches or substance abuse
- High daily caffeine consumption
- Physical inactivity
- Assigned female at birth
Studies suggest genetics may also play a role in rebound headaches.
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How often can I take Imitrex?
It isn’t known how safe it is to take Imitrex to treat more than 4 headaches per month. If you need to treat your headaches more often, consult with your healthcare provider. It is best to avoid taking headache medications for more than 10 days per month in order to avoid rebound headaches. If you are having frequent headaches, talk to your doctor about preventative options.
References
Brar, Y., et. al. (2023). Sumatriptan. In: StatPearls [Internet]. Accessed 06/27/2024 at https://www.ncbi.nlm.nih.gov/books/NBK470206/
Fischer, M. A., et. al. (2023). Medication-Overuse Headache. In: StatPearls [Internet]. Accessed 06/27/2024 at https://www.ncbi.nlm.nih.gov/books/NBK538150/
Imitrex tablet [package insert]. (Revised Feb 2024). Accessed 06/27/2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=584abe73-8290-4484-ff8e-5890831c095e
Read next
How long does Imitrex (sumatriptan) take to work?
Imitex (sumatriptan) can start to work within 30 minutes of taking a dose. However, it may take a few hours for you to notice the full effects. Continue reading
How often can you take Imitrex (sumatriptan)?
How often you can take Imitrex (sumatriptan) depends on which form you are taking. Imitrex comes as a tablet, nasal spray, and injection. Each form of Imitrex has its own specific dosing recommendations. Do not take more Imitrex than what’s prescribed to you, since taking too much can lead to serious side effects. Continue reading
Can depression cause headaches?
Yes, headaches can be a symptom of depression, among many other symptoms such as feeling sad, tearful and loss of interest in everyday activities. An association with depression has also been identified in patients with migraine headaches. Severe headaches may also cause a person to feel depressed. Continue reading
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