Zithromax Dosage
Generic name: AZITHROMYCIN DIHYDRATE 250mg
Dosage forms: tablet, film coated, oral suspension
Drug class: Macrolides
Medically reviewed by drugclasses.com. Last updated on Apr 15, 2024.
Adult Patients
[see Indications and Usage (1.1) and Clinical Pharmacology (12.3)]
Infection* | Recommended Dose/Duration of Therapy |
---|---|
|
|
Community-acquired pneumonia Pharyngitis/tonsillitis (second-line therapy) |
500 mg as a single dose on Day 1, followed by 250 mg once daily on Days 2 through 5 |
Acute bacterial exacerbations of chronic obstructive pulmonary disease |
500 mg once daily for 3 days |
Acute bacterial sinusitis |
500 mg once daily for 3 days |
Genital ulcer disease (chancroid) |
One single 1 gram dose |
Non-gonococcal urethritis and cervicitis |
One single 1 gram dose |
Gonococcal urethritis and cervicitis |
One single 2 gram dose |
ZITHROMAX tablets can be taken with or without food.
Pediatric Patients1
Infection* | Recommended Dose/Duration of Therapy |
---|---|
1 see dosing tables below for maximum doses evaluated by indication | |
|
|
Acute otitis media |
30 mg/kg as a single dose or 10 mg/kg once daily for 3 days or 10 mg/kg as a single dose on Day 1 followed by 5 mg/kg/day on Days 2 through 5. |
Acute bacterial sinusitis |
10 mg/kg once daily for 3 days. |
Community-acquired pneumonia |
10 mg/kg as a single dose on Day 1 followed by 5 mg/kg once daily on Days 2 through 5. |
Pharyngitis/tonsillitis |
12 mg/kg once daily for 5 days. |
ZITHROMAX for oral suspension can be taken with or without food.
PEDIATRIC DOSAGE GUIDELINES FOR OTITIS MEDIA, ACUTE BACTERIAL SINUSITIS, AND COMMUNITY-ACQUIRED PNEUMONIA
(Age 6 months and above, [see Use in Specific Populations (8.4)])
Based on Body Weight
Dosing Calculated on 10 mg/kg/day Day 1 and 5 mg/kg/day Days 2 to 5. | ||||||
---|---|---|---|---|---|---|
Weight | 100 mg/5 mL | 200 mg/5 mL | Total mL per Treatment Course |
Total mg per Treatment Course | ||
Kg | Day 1 | Days 2–5 | Day 1 | Days 2-5 | ||
|
||||||
5 |
2.5 mL; (½ tsp) |
1.25 mL;(¼ tsp) |
7.5 mL |
150 mg |
||
10 |
5 mL; (1tsp) |
2.5 mL; (½ tsp) |
15 mL |
300 mg |
||
20 |
5 mL; (1 tsp) |
2.5 mL; (½ tsp) |
15 mL |
600 mg |
||
30 |
7.5 mL; (1½ tsp) |
3.75 mL; (¾ tsp) |
22.5 mL |
900 mg |
||
40 |
10 mL; (2 tsp) |
5 mL; (1 tsp) |
30 mL |
1200 mg |
||
50 and above |
12.5 mL; (2½ tsp) |
6.25 mL; (1¼ tsp) |
37.5 mL |
1500 mg |
Dosing Calculated on 10 mg/kg/day. | ||||
---|---|---|---|---|
Weight | 100 mg/5 mL | 200 mg/5 mL | Total mL per Treatment Course | Total mg per Treatment Course |
Kg | Days 1–3 | Days 1–3 | ||
|
||||
5 |
2.5 mL; (1/2 tsp) |
7.5 mL |
150 mg |
|
10 |
5 mL; (1 tsp) |
15 mL |
300 mg |
|
20 |
5 mL (1 tsp) |
15 mL |
600 mg |
|
30 |
7.5 mL (1½ tsp) |
22.5 mL |
900 mg |
|
40 |
10 mL (2 tsp) |
30 mL |
1200 mg |
|
50 and above |
12.5 mL (2 ½ tsp) |
37.5 mL |
1500 mg |
Dosing Calculated on 30 mg/kg as a single dose. | |||
---|---|---|---|
Weight | 200 mg/5 mL | Total mL per Treatment Course | Total mg per Treatment Course |
Kg | 1-Day Regimen | ||
5 |
3.75 mL;(3/4 tsp) |
3.75 mL |
150 mg |
10 |
7.5 mL;(1½ tsp) |
7.5 mL |
300 mg |
20 |
15 mL;(3 tsp) |
15 mL |
600 mg |
30 |
22.5 mL;(4½ tsp) |
22.5 mL |
900 mg |
40 |
30 mL;(6 tsp) |
30 mL |
1200 mg |
50 and above |
37.5 mL;(7½ tsp) |
37.5 mL |
1500 mg |
The safety of re-dosing azithromycin in pediatric patients who vomit after receiving 30 mg/kg as a single dose has not been established. In clinical studies involving 487 patients with acute otitis media given a single 30 mg/kg dose of azithromycin, 8 patients who vomited within 30 minutes of dosing were re-dosed at the same total dose.
Pharyngitis/Tonsillitis: The recommended dose of ZITHROMAX for children with pharyngitis/tonsillitis is 12 mg/kg once daily for 5 days. (See chart below.)
PEDIATRIC DOSAGE GUIDELINES FOR PHARYNGITIS/TONSILLITIS
(Age 2 years and above, [see Use in Specific Populations (8.4)])
Based on Body Weight
Dosing Calculated on 12 mg/kg/day for 5 days. | |||
---|---|---|---|
Weight | 200 mg/5 mL | Total mL per Treatment Course | Total mg per Treatment Course |
Kg | Day 1–5 | ||
8 |
2.5 mL; (½ tsp) |
12.5 mL |
500 mg |
17 |
5 mL; (1 tsp) |
25 mL |
1000 mg |
25 |
7.5 mL; (1½ tsp) |
37.5 mL |
1500 mg |
33 |
10 mL; (2 tsp) |
50 mL |
2000 mg |
40 |
12.5 mL; (2½ tsp) |
62.5 mL |
2500 mg |
Constituting instructions for ZITHROMAX Oral Suspension 300, 600, 900, 1200 mg bottles. The table below indicates the volume of water to be used for constitution:
Amount of water to be added | Total volume after constitution (azithromycin content) |
Azithromycin concentration after constitution |
---|---|---|
9 mL (300 mg) |
15 mL (300 mg) |
100 mg/5 mL |
9 mL (600 mg) |
15 mL (600 mg) |
200 mg/5 mL |
12 mL (900 mg) |
22.5 mL (900 mg) |
200 mg/5 mL |
15 mL (1200 mg) |
30 mL (1200 mg) |
200 mg/5 mL |
Shake well before each use. Oversized bottle provides shake space. Keep tightly closed.
After mixing, store suspension at 5° to 30°C (41° to 86°F) and use within 10 days. Discard after full dosing is completed.
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